Friends of Derek and Addison's from NY come to Seattle but not for a social visit. The wife would like a preventative hysterectomy and mastectomy because she just discovered she has a gene that makes her susceptible to cancer in those regions. The wife wants the surgery, the husband thinks she's going too far, and the doctors -- including Izzie who's on the case -- are all in between. George nearly gets trampled by a window washer who falls from a high window.

  The man survives because he lands on a pigeon, and is taken to the hospital. George thinks it's a miracle this guy survived, but the guy has a different take on things. Meredith and Bailey work with a couple where the wife finds out she has only a few months to live. She asks them not to tell her husband, but they already have -- and when told the news, the husband asks them not to tell the wife. They both want to protect the other from the news. Cristina and Burke go on a date, but it's not going so swimmingly at all -- until the date turns into a case when a fellow patron at the restaurant needs medical attention. It turns out to be the best date ever.