Meredith: [voiceover] Gratitude, appreciation, giving thanks. No matter what words you use, they all mean the same thing. Happy. We're supposed to be happy. Grateful for friends, family. Happy just to be alive. Whether we like it or not.

Cristina': [about inviting Burke to Thanksgiving dinner] What was I supposed to do? Blow off my boyfriend for Thanksgiving? I tried to. He wouldn't blow. He's like something sticky that won't blow off.

George: [about his Thanksgiving, hunting with his family] I'm in the woods. With shotguns and liquor and car talk. It's like Deliverance out here!

Cristina: Meredith's a WASP, isn't she? Liquor is like oxygen for WASPs.

George: Which is...why we're out of liquor.

Joe: Hey, this is my boyfriend, Walter.

Cristina: Whatever, tell me you brought liquor.

Joe: I brought pie. Pumpkin.

Cristina: You're a bartender!

Joe: Did you bring scalpels?

Alex: [To Meredith, about telling Izzie he failed his Medical Board Exam] If I tell Izzie, she'll be nice about it, all supportive and optimistic—she might as well rip my nads off and turn them into earrings.

Meredith: I feel like one of those people who are so freaking miserable that they can't be around normal people. Like I'll infect the happy people. Like I'm some miserable, diseased, dirty ex-mistress.

Alex: A miserable, diseased, dirty ex-mistress? [Wolf whistle] That's hot. That's really hot. I feel better already.

George: Today I committed bird murder and I was forced to touch my dad's ass. I get bonus points for showing up at all.

Cristina: I brought booze.

Meredith: [voiceover] Maybe we're not supposed to be happy. Maybe gratitude has nothing to do with joy. Maybe being grateful means recognizing what you have for what it is. Appreciating small victories. Admiring the struggle it takes simply to be human. Maybe we're thankful for the familiar things we know. And maybe we're thankful for the things we'll never know. At the end of the day, the fact that we have the courage to still be standing is reason enough to celebrate.