EXPLORE All The Shades of Grey

Meredith: [voiceover] Fresh starts thanks to the calendar they happen every year —just set your watch to January, our reward for surviving the holiday season is a new year. Bringing on the great tradition of new years resolutions, put your past behind you and start over. It’s hard to resist the chance of a new beginning, a chance to put the problems of last year to bed.

Meredith: Such a good dog! Who's Mommy's good boy? [Turns and looks at Izzie and George] C'mon, what are you doing, we're gonna be late.

George: Uh— We need to talk about the dog.

Izzie: That's not a dog, it's a hyena that escaped from the zoo, dressed in dog clothing.

George: Whatever. I don't chew up his clothes. I don't urinate on his bed. I don't try to mount him from behind.

Meredith: People, he's our dog. We love our dog. He loves us.

Izzie: Mount you from behind?

George: He tries to.

Izzie: You do glow.

Alex: Like the moon.

Bailey: And you can spend the day in the pit Karev.

George: Your lab work showed... have you been taking birth control pills?

Bex: If you tell my mom and dad they'll-

George: I won't! I won't—I just need to know...why? Do you have a boyfriend?

Bex: Like anyone would want to have sex with me—

George: Well...then...why?

Bex: I'm as flat as a board. I took like five of those pills a day and nothing's different. Boobs, dude.

George: You...were trying to make your breasts grow.

Bex: I wanted to be normal for once in my life.

Derek: [to Addison] There is a land called Passive Agressiva, and you are their queen.

Addison: I am fine.

Derek: Except when you're shrieking about trout.

Addison: I was not shrieking about trout.

Derek: You're right, you weren't. You were shrieking about Meredith.

Addison: No, I was shrieking about the trailer. I hate the trailer.

Derek: Oh, okay so the past three weeks have been about the trailer, not about the fact that I said I love Meredith.

Addison: Loved— you said you loved her, past tense.

Derek: Right, yes, past tense.

Addison: Well, then I have been shrieking about the trailer.

Denny: Can I ask you something personal?

Izzie: If I say no?

Denny: I'll hold my breath, which will stop my heart, killing me. You're right here, you'll be charged with murder. Lifetime in prison loved by a big old girl named Hildy.

Izzie: So my choices are homicide charges or inappropriate personal questions from a patient.

Denny: I know, kind of sucks.

Izzie: You know what, hold your breath. I'll take my chances with Hildy. I can do girl-on-girl.

Denny: Oh, you're bringing up girl-on-girl? How can I blackmail you if you bring up girl-on-girl?

Izzie: What do you want to know?

Denny: That guy Alex. You with him?

Izzie: No, not anymore and never ever again.

Denny: Good, that means I won't have to fight him for you.

Izzie: What makes you think I want you to fight him for me?

Denny: You're in love with me. I'm well-off, but not into money; I'm smart, but not a know-it-all; I'm funny, I'm really nice, I love animals— and I'm hot. I'm a catch, if you can wrap your head around the enlarged failing heart and dependency to IV meds.

Izzie: You're right. I am so in love with you. It's a shame, really, since I'm with Hildy and all.

Bailey: Yang, why are you staring at my fat pregnant belly?

Meredith: My mother is very sick and has very few good days. And I don't want her to be poked and prodded for some experimental program.

Derek: I'm just trying to help.

Meredith: Well, see this? What you’re doing, being dreamy? It doesn't help. It hurts me. It messes with my head.

Derek: I know the feeling.

Meredith: I don't doubt that. But you, you have a wife to go home to and I'm guessing she has no idea where you are right now.

Derek: No, she doesn't.

Meredith: That's what I thought.

Meredith: [voiceover] Who gets to determine when the old ends and the new begins? It’s not on the calendar, it’s not a birthday, it’s not a new year, it’s an event —big or small, something that changes us, ideally it gives us hope, a new way of living and looking at the world, letting go of old habits, old memories. What's important is that we never stop believing we can have a new beginning, but it's also important to remember amid all the crap are a few things really worth holding on to.