Meredith: [voiceover] After careful consideration and many sleepless nights, here’s what I've decided. There's no such thing as a grown-up. We move on, we move out, we move away from our families and form our own. But the basic insecurities, the basic fears and all those old wounds just grow up with us. And just when we think life and circumstances have forced us truly to become an adult, your mother says something like that. Or worse, something like that. We get bigger, we get taller, we get older. But, for the most part, we're still a bunch of kids, running around the playground, trying desperately to fit in.

Cristina: [about Burke] You know, he’s acting like I committed a crime. Like my apartment is full of stolen goods. He’s acting like I kept my apartment to hide stolen goods so I could do illegal transplants for money.

Meredith: Are you sure he’s not just acting like you lied to him about moving in?

Cristina: What the hell's wrong with you?

Meredith: My mommy’s a filthy whore.

Izzie: You have dirty in your eyes.

Alex: You have dirty in your eyes.

Izzie: I'm not doing dirty with you anymore. It was a one-time lapse in judgment

Alex: No it was a four-time lapse in judgment.

Izzie: Well, it’s not gonna happen again

Alex: Oh, ok.

Izzie: I'm serious. We're friends and it didn’t work when we tried to be more than that, so, as fun as it was, it’s not gonna happen again.

George: How do I look today? Would you say that I look nice?

Izzie: Well, you could use a little more lip gloss but yes, you’re very pretty.

George: Aw, you're mean.

Izzie: I'm just kidding, you look fine.

George: Seriously, how’s my breath?

Izzie: George, would you just talk to her?

Chief: Punching out people on my surgical floor. My head of neurosurgery punching out people on my surgical floor.

Addison: Put the ice on your hand.

Derek: My hand is fine.

Chief: Put the damn ice on your two million a year hand. Now, would someone tell me what the hell happened?

Addison: That was Mark.

Chief: Who’s Mark?

Addison: He and Derek used to work together back in New York. And they, we, were all close friends. Until Derek found us in bed together.

Chief: Did you put your weight behind it?

Derek: Yes sir.

Chief: Well, all right then.

Mark: Derek and I always did have the same taste in women

Meredith: Excuse me?

Mark: You're Derek’s lusty intern, right? I've heard about you all the way back in New York. You're famous.

Meredith: Well, I heard about you all the way here in Seattle, so I guess we have a lot in common.

Mark: We're the dirty mistresses.

Meredith: I suppose we are.

Mark: My 400 dollar an hour shrink says that it’s because behind this rugged and confident exterior, I'm self destructive and self-loathing to an almost pathological degree.

Meredith: Hey, we do have a lot in common.

Mark: You know, it’s funny, Derek walks in on me naked with his wife, actually in the throes, and he just turns around and walks away. But he sees me so much as talking to you, and I'm on the ground bleeding. Interesting, don't you think?

George: Why is he suturing his own face?

Cristina: To turn me on.

Alex: Because he’s Mark Sloan, he’s like the go-to plastic surgeon on the east coast.

George: That’s the guy Addison was sleeping with?

Izzie: You can’t really blame her, can you?

Cristina: No, not really

George: Yes, you can

Meredith: McSexy wants an X-ray to check for fractures and I think it’s a bad idea if I take him.

George: Why? Why?

Alex: I'm on it

George: Why's it a bad idea?

Cristina: McSexy?

Meredith: No?

Izzie: McYummy?

Meredith and Cristina: No.

Meredith: McSteamy.

Cristina: Aw, there it is.

Izzie: Yep.

George: Excuse me, I'm just choking back some ... McVomit.

Izzie: You know when you don’t have sex for a while you sort of forget how good it is and you don't really need it as much?

George: Yeah, that doesn't happen to guys.

Izzie: It’s like a beast, a beast that was asleep for a long, long time. And now the beast is wide-awake and wants to be fed and the food that Alex gave it-- it was good food George.

George: Something needs to be done about your taste.

Izzie: Ah, you’re just jealous because your beast is still asleep.

George: My beast isn’t asleep. My beast never sleeps.

Cristina: [about Addison] I don't get what McDreamy and McSteamy see in her.

Alex: She's McHot!

George: McYeah she is!

Mark: I'm hoping Addison shows up.

Meredith: You're still in love with her?

Mark: You're still in love with him.

Cristina: Um--

Burke: I am Preston Burke, a widely renowned cardiothoracic surgeon. I am a professional. And more than that I am a good and kind person. I am a person that cleans up behind myself. I am a person that cooks well. And you, you are an unbelievable slob. A slovenly, angry intern. I am Preston Burke. And you, you are the most competitive, most guarded, most stubborn, most challenging person I have ever met. And I love you. What the hell is the matter with you that you won’t just let me?

Cristina: I gave up my apartment 20 minutes ago.

Burke: Well, alright then.

Meredith: [voiceover] I've heard that it’s possible to grow up, I've just never met anyone who’s actually done it. Without parents to defy, we break the rules we make for ourselves. We throw tantrums when things don’t go our way. We whisper secrets with our best friend, in the dark. We look for comfort where we can find it. And we hope against all logic, against all experience, like children, we never give up hope.