Meredith: To make it - really make it - as a surgeon - it takes major commitment. We have to be willing to pick up that scalpel and make a cut that may or may not do more damage than good. It's all about being committed, because if we're not? We have no business picking up that scalpel in the first place.

George: Okay, I'll be Cristina for you, if you'll be Izzie for me.

Meredith: Deal.

[George stops the elevator]

Meredith: Derek had a woman in his trailer last night. She was ugly, very ugly, except she was tall and beautiful. And he was naked.

George: Oh. Uh, McDreamy was doing the McNasty with McHottie? That McBastard. Uh, how was that?

Meredith: That was good.

George: Cristina enough? [Meredith nods] Really?

Meredith: Yeah.

George: Yeah?

Meredith: Yeah.

George: Excellent.

Meredith: Chanelling Izzie. Go.

George: Okay, uh, Callie... she won't forgive me. Uh, she won't talk to me. She dumped me. Which is uh, I don't care about, you know, at all...

Meredith: Good because you deserve better. You do. You are George. I mean seriously. Seriously. Seriously. Was that Izzie optimistic?

George: [a little stunned] Yes, it's very Izzie. [both of them sigh]

Meredith: What the hell has happened to us?

George: We are now the people that the people we want to be with avoid.

Meredith: We have careers to think about. We don't need attention from men with perfect hair.

George: You know, we should make a pact. There's no more dating.

Meredith: [nodding] No more Derek. No more Callie.

George: Just a hundred percent focused on our work.

Meredith: They're dead to us.

George: They're freakin' corpses to us. [knocks fists with Meredith]

Nancy: [Derek's sister] Oops, I take it that was the slutty intern you cheated on Addison with?

Derek: She's not slutty. What are you doing here?

Nancy: You bailed on Thanksgiving and Christmas and you live in a trailer and you're getting a divorce and then there's the slutty intern.

Derek: I really don't like you.

Nancy: You love me.

Izzie: McDreamy's McSister's McBitchy! [laughs]

Derek: You sound more and more like Mom every day.

Nancy: Take it back!

Nancy: What are you doing here, Mark? Are you trying to torture him?

Mark: He's my family, Nancy. Plus I needed a change of pace. [Nancy gives him an unconvinced look] Plus I slept with my tennis partner's wife and he went out and bought a gun.

Derek: Four sisters - four sisters! Not one brother; and you wonder why I don't call more.

Nancy: So, tell me about the slutty girl... Fine, the slutty intern.

Derek: It was the 'slutty' part I had a problem with.

Callie: [to George] I'm out of my element here, I break bones for a living, I used to live in the basement, most days I wear last night's eyeliner to work, and I don't give a crap about what other people think of me. Because I am a happily independent and successful woman and I like it that way, only when you say stuff like this, it just makes things too hard. So please, don't chase me anymore, unless you're ready to catch me.

Meredith: [voiceover] There are times when even the best of us have trouble with commitment, and we may be surprised at the commitments we're willing to let slip out of our grasp. Commitments are complicated. We may surprise ourselves by the commitments we're willing to make. True commitment, takes effort, and sacrifice. Which is why sometimes, we have to learn the hard way, to choose our commitments very carefully.