Mr. O'Malley: If things go wrong, the life insurance papers are in the second drawer in my nightstand, and my [pause] magazines are in the garage with the truck mags.

George: Your magazines?

Mr. O'Malley: Get 'em outta there so your Ma doesn't see them?

George: Your magazines?!

Izzie: Yang does something wrong and she gets rewarded. That's fair.

George: Yeah.

Bailey: If you thumb-suckers don't stop whining, I swear I won't show you what's behind this door. And trust me, you wanna see what's behind this door. [She opens the door, revealing conjoined adult twins. Alex and Izzie smile while George looks on amazed]

Chief: Why are you researching neurosurgeons when you and I both know that Derek's better than anybody?

Burke: I don't want Shepherd.

Chief: You blame this on him? Up until now, I have not yelled. I have not yelled because you are a guy in trouble and I was supporting you. But now I am yelling!

Burke: Chief.

Chief: I am yelling very loudly!!! I wanna retire, Burke! I want my wife back and I passed the torch to you! I passed the torch to you and you blew it out!

Burke: I know I let you down.

Chief: Burke, I'm tired. I'm tired of you men acting like boys. You let me down and if you don't let Derek fix that hand, you're letting yourself down.

Alex: [to Cristina] You're here? You haven't been kicked out of the program yet?

Meredith: Alex.

Cristina: No, not yet. I'm still here.

Alex: How did you do it? I mean, did you have some kinda signal in surgery so that the nurses wouldn't know? Or did you-

Meredith: Alex.

Alex: What? I'm just wondering how to get ahead around here. Me? I get coffee for Sloan and Yang gets surgeries none of us would get.

George: Got a head count of how many patients you two lied to the past month?

Meredith: George.

Izzie: Leave her alone. Her patients live so she gets to scrub in.

Meredith: Izzie.

Cristina: Meredith, please can you just stop defending me? [leaves]

Mr. O'Malley: You're so angry.

George: I'm not.

Mr. O'Malley: You've been picking fights every chance you get and that's not like you.

George: Dad. You don't know what's been going on.

Mr. O'Malley: Okay then tell me. Why are you so mad at Dr. Torres?

Callie: I should go. I have patients to see.

George: No, you know what, I'm going to go.

Mr. O'Malley: No! Everybody stays! You're angry, Georgie. At Callie, at your brothers, at Dr. Hahn, at Dr. Bailey, at Dr. Yang, at Dr. Burke! That's a long list of people to be angry at. Especially when the person you're really angry at, is me.

George: Dad?

Mr. O'Malley: I drank and I smoke and I won't evercise and I eat all the wrong things and now, I have [pause] cancer. And you have to take care of everything. You have to take care of me.

George: I don't mind.

Mr. O'Malley: You do. You're mad at me and that's okay because I'm mad at me too. You think I wanna die and leave my boy in charge?

George: You're not going to die.

Dr. Hahn: You remind me of myself when I was an intern.

Cristina: I do?

Dr. Hahn: Focused, intense, cold, and I don't mean that as a bad thing, cold is good. The dating, the friends and the family, if you ask me, it's all overrated.

Derek: It'd be nice if every love triangle could be fixed with a scalpel.

Mark: If they could, you would have stabbed me with a ten blade a long time ago. [they both laugh]

Bailey: I was responsible for Izzie Stevens. I was responsible and I'm responsible for Cristina Yang. I am the common thread here. I. Lost them, Cristina, Izzie.

Chief: Are not the same. Miranda, you raised them. You raised them like [pause] like children and some of them make mistakes and some of them disappoint you. Some of them. Do you know what kinda strength it must have taken for Yang to come to me? To report on an attending? On her boyfriend? Do you see how much she's grown? You raised them like children and some of them turn out exactly like you Dr. Bailey.

Meredith: I can't take this anymore!

Izzie: What?

Meredith: Let her off the hook. Let Cristina off the freaking hook.

Cristina: Meredith!

Meredith: Izzie, you cut the LVAD wire, she stuck by you and did Denny's ECHO. [to Alex] You cheated on Izzie with syph nurse and she helped you study for your boards. And George, when everybody was calling you 007-

George: [angrily] She was calling me 007. [leaves]

Meredith: Just let her off the hook.

Alex: It's okay.

Izzie: Sorry. [Alex and Izzie leave]

Cristina: Why can't you mind your own business, you know? What is your problem?

Meredith: You're my sister. You're my family. You're all I've got.

Cristina: [puts her head on Meredith's shoulder] I'm so tired.

Meredith: I know, me too.

Meredith: [voiceover] At the end of the day, when it comes down to it, all we really want is to be close to somebody. So this thing where we all keep our distance and pretend not to care about each other, it's usually a load of bull. So we pick and choose who we want to remain close to, and once we've chosen those people, we tend to stick close by. No matter how much we hurt them. The people that are still with you at the end of the day, those are the ones worth keeping. And sure, sometimes close can be too close. But sometimes, that invasion of personal space, it can be exactly what you need.