EXPLORE All The Shades of Grey

Meredith [voiceover] In the practice of medicine, change is inevitable. New surgical techniques are created, procedures are updated, levels of expertise increase. Innovation is everything, nothing remains the same for long. We either adapt to change, or we get left behind.

[The new residents meet their new interns.]

Cristina: [to interns] I have five rules. Memorize them. Rule number one, don't bother sucking up. I already hate you, that's not gonna change.

Izzie: Traumas protocol, phone lists, pagers. The nurses will page you, you answer every page at a run. A run. That's rule number two. [notices the interns are not following her] You're supposed to follow me.

Alex: The first shift starts now and lasts 36 hours. You're grunts, nobodies, the bottom of the surgical food chain. You run labs, write orders, work every second night until you drop. And you don't complain.

Meredith: On call rooms. Sleep when you can, where you can. You know, but not with anybody. Not attendings, especially not attendings. Sleeping with attendings, not a good idea. Where was I?

George: Er, rule number three. If you're sleeping, do not wake you unless the patient is actually dying.

Cristina: The dying patient better not be dead when I get there, because not only will you have killed someone, you will have woken me for no good reason. Are we clear? [Lexie raises her hand] Yes?

Lexie: That was four rules. You said five.

Cristina: Rule number five. When I move, you move. [awkward pause as nobody moves] Go! [Cristina's interns scramble off]

[George comes into room]

Cristina: Ah, George! Severed arm, Meredith's half sister is my intern, Izzie's playing Dr. Doolittle, oh, and Alex hates your wife.

Derek: How is Meredith, anyway?

Cristina: Fine.

Derek: She's always fine. That's her problem.

Cristina: We're fine people. We do fine. We're fine.

Derek: [to Lexie] You're the girl from the bar.

Meredith: Girl from the bar? I'm the girl from the bar.

Alex: Torres is a bitch.

Izzie: Word!

Izzie: [to George] I tell you that I love you, and not one word? For 17 days? Where have you been?

Izzie: I'm Bambi. I'm Bambi, George. If anyone in this situation is a sad little cartoon character, it's me. I'm all alone in the forest, all alone in the forest, George. And my mother's been shot by a hunter and where are you? Where the hell are you?

Nancy: I can't do any of this alone. I don't want to be alone anymore.

Meredith: I know.

Nancy: No, I'm scared.

Meredith: I know.

Nancy: I am scared, Meredith.

Nancy: I know.

Meredith: I think it's very brave, what you're doing. It's much better to be alone and feel like a success than to be in a relationship and feel like a failure all the time, right?

Nancy: That's what I think.

Meredith: So let's just take care of your arm, and then we'll deal with the rest later, okay?

Mark: I didn't come to Seattle for Addison, I didn't come to Seattle to be chief. I came to Seattle for you, okay? I came to Seattle to get you back. (Both smile).I know I wanna take it back, but now, it's said. (laughs a little about himself)

Derek: Yeah...May be we should have a drink.

Mark: We could?

Derek: Yeah. (smiles) (stops smiling) Not today.

(Left Mark standing, but stupid smiling)

Meredith: I...uhm...

Derek: You're not ready for this.

Meredith: No.

Derek: I asked for too much.

Meredith: I think so.

Derek: So, this is it?

Meredith: Yeah.

Derek: We're breaking up?

Meredith: We're breaking up.

Derek: [Walks to Meredith] We're broken up.

Meredith: It's done.

[They start kissing]

Derek: Break-up kiss.

Meredith: Break-up kiss.

Derek: [Removes his jacket] And some break-up sex.

Meredith: Yeah, break-up sex.

Christina: Oh, why is everyone so tingly and hurt? I mean, I'm the one who was left at the altar. I'm fine, by the way. I honeymooned in Hawaii and I snorkeled.

Mark: I really am up for a drink, you know if you need to talk.

Derek: What would I need to talk about?

Mark: Meredith. You were lucky, man. That girl jerked you around.

Derek: You have no idea what you're talking about.

Mark: Hey, I'm just... seem like you can use a friend right about now.

Derek: Meredith's mother never wanted her and her father was never man enough to hang around. She has a right to be damaged and us, together? It's a big step for her. Her best friend gets left at the altar, and all she sees now is things like this, they don't work. She panics. She wants this, she doesn't know how to have it. And you know what? It's not her fault. So don't ever talk to me about Meredith Grey again because you do not know what you are talking about. And I don't want a friend.

Meredith: Change; we don’t like it, we fear it, but we can't stop it from coming. We either adapt to change or we get left behind. And it hurts to grow, anybody who tells you it doesn’t is lying. But here's the truth: the more things change, the more they stay the same. And sometimes, oh, sometimes change is good. Oh, sometimes change is everything.

George (to Izzie): I love you too