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Dream a Little Dream of Me 3 Here Comes the Flood 4 Brave New World 5 There's No 'I' in Team 6 Life During Wartime 7 Rise Up 8 These Ties That Bind 9 In the Midnight Hour 10 All By Myself 11 Wish You Were Here 12 Sympathy for the Devil 13 Stairway to Heaven 14 Beat Your Heart Out 15 Before and After 16 An Honest Mistake 17 I Will Follow You Into the Dark 18 Stand By Me 19 Elevator Love Letter 20 Sweet Surrender 21 Not Good at Saying Sorry (One More Chance) 22 What a Difference a Day Makes 23 Here's to the Future 24 Now or Never

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Meredith feels the pain of being torn between her boyfriend who wants her to kick out all her other roommates and her friends, who need a place to live. Retaking the intern exam is George's pain. And nothing says pain to Cristina like NOT being on the cardiothoracic surgery rotation. But, none of these compare to Derek's patient, Phillip Patmore's pain. He has been living with an intense unrelenting headache for seven years!

When it was clear that a simple aspirin wasn't going to stop the Phillip's pain, doctors prescribed narcotics, anti-seizure medications, antidepressants, anti-psychotics. None of these worked. Phillip's tried everything except having part of his brain surgically removed and that is exactly what Dr. McDreamy, pain specialist and neurosurgeon extraordinaire is about to do.

The procedure is called a bilateral cingulotomy. Derek opens into Phillip's skull, targets part of his frontal lobe and removes two small pieces of his brain. It's so radical that it is only done in cases of extreme and unmanageable pain or OCD. The risks are serious: seizures, cognitive defects and behavioral changes and no one knows exactly why this technique works

But, right before the surgery, Lexie Grey, Meredith's younger sister with a photographic memory, remembers an obscure condition of a pinched sinus nerve which is described as the worst pain you'll ever know. Lexie makes a connection. What if Phillip's headache is actually caused by a pinched sinus nerve?

Inside the nasal passages there are turbinates, which regulate the flow of air through the nose. They filter out harmful particles and add moisture to the air and warm it before it travels to the lungs. Sometimes a previous infection or a trauma causes a glitch and a nerve in Phillip's case the ethmodial nerve gets trapped between one of these turbinates and the nasal septum. It's called a "contact point" or "trigger". Because this condition is so rare, the most difficult part of the diagnosis is thinking of it. Usually sinus headaches involve inflammation and swelling of the sinuses. But in Phillips case he had no current sinus infection or swollen sinus tissue, so doctors had not considered this as a possibility. Once it is suspected, there are two easy ways to rule out or confirm the diagnosis. The first, while the pain is in evidence, put anesthetic on it. If the headache goes away, then a trapped ethmodial nerve is indeed the problem. The second way is to push on the trigger and if the patient screams in pain. Either way a simple surgery to clear out the blockage that is putting pressure on the nerve will fix the problem permanently.

While Lexie is sometimes the cause of Mereidth's pain, for Phillip Patmore, little Lexipedia saved the day!