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One of the questions I'm often asked is,"How has your job as Medical Researcher of Grey's Anatomy changed your attitudes toward medicine." The answer is, when I renewed my driver's license this time, I signed up to be an organ donor. One thing Grey's Anatomy (and Denny Duquette) has taught me is there just aren't enough organs from deceased donors to go around. In 1954, doctors began performing living organ transplants when a living person donates a kidney or part of their liver to a loved one who is in need of an organ. While living organ donation hasn't solved the organ shortage, it has definitely helped close the gap. It's also created an additional problem, what if someone in your life is generous enough to give you a kidney but their kidney doesn't match? In episode 505, There's No"I" in Team, Dr. Miranda Bailey creates an innovative program that provides an answer to that... The Domino Kidney Transplant.

You know how when you stand up dominos in a pattern and knock one over all of the dominoes fall over in quick succession? That's just what Bailey did with the domino kidney transplants. She found someone who needs a kidney and had someone in his or her life who was not a match, but was willing to give up a kidney to help. Bailey found five other donor/recipient pairs in this same situation and she paired them up one by one, until there were five recipients and six donors who matched and are ready to go. What happened to the sixth kidney?

The United Network for Organ Sharing (UNOS) has developed a system of organ allocation that is fair. Well, as fair as it can be when dealing with something as fundamentally unfair as life-threatening illness. In cases of directed donation (like if your sister gives you a kidney) the ethics is straightforward. The donor has the right to decide who she gifts her organ to. But, as soon as a licensed transplant center gets involved with the pairing process, the ethics becomes more difficult. The rules say the person at the top of the list gets the next kidney. Doctors don't allocate organs. UNOS does. Yet, Bailey knows six people who are willing to donate organs in order for their loved ones to receive the organs. With such a grave organ shortage it seems a shame not to take them up on their generosity. So, this problem is solved when one of the kidneys is given to the person at the top of the list. They become the sixth recipient.

Who is the sixth donor? Where did they come from? Typically the sixth donor is what is called an altruistic donor. Someone who wants to donate an organ just to be generous. This altruistic donor is actually the first domino that trips the chain reaction, because without the unpaired kidney there would be no kidney to pair with the person at the top of UNOS's list.

Now for the question that everyone wants answered: Would the kidney that Meredith dropped really be used? I'll answer that question with a question. Now that you know how rare a good kidney is and how much work goes into pairing kidneys and recipients what do you think?

For more information on Kidney Transplants or becoming an organ donor go to: www.donatelife.net