Dream a Little Dream of Me 3 Here Comes the Flood 4 Brave New World 5 There's No 'I' in Team 6 Life During Wartime 7 Rise Up 8 These Ties That Bind 9 In the Midnight Hour 10 All By Myself 11 Wish You Were Here 12 Sympathy for the Devil 13 Stairway to Heaven 14 Beat Your Heart Out 15 Before and After 16 An Honest Mistake 17 I Will Follow You Into the Dark 18 Stand By Me 19 Elevator Love Letter 20 Sweet Surrender 21 No Good at Saying Sorry (One More Chance) 22 What a Difference a Day Makes 23 Here's to the Future 24 Now or Never

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Derek figures out a way to get to Izzie's tumor. He wants to remove part of her hippocampus, a common surgery for seizure patients, but one that could affect her memory and her speech. Given the severe possible side effects, Izzie is reluctant to go that route. Dr. Swender wants to try her on IL2 medicine, which has kept her "miracle" patient alive and tumor-free for two years.

To see how Izzie's memory might be affected by the surgery, they do a test where they show her flashcards and then ask her to say what was on them, repeating it with the right half of her brain has been put to sleep. She's unable to speak or even nod when Meredith asks her to tell her who Alex is. Dr. Swender and Meredith are adamantly opposed to the surgery and after talking to the IL2 patient, Izzie decides to try the less radical approach.

Alex wants to know what Derek would do: "What if it was Meredith?" he asks. Derek tells him, "I would ask her to have the surgery."

Owen tells Cristina he's had a good session with his shrink, but she wants to know when he's going to tell his mother he's back from Iraq. George works with Owen on a patient, an ex-soldier with constant, excruciating pain in his leg. The doctors can't find anything wrong, but the soldier wants them to cut if off so he can get back to Iraq. George asks the soldier why he wants to go back so badly and he explains that he has nothing in common with his relatives and that the guys in Iraq are his "real family."

Arizona wants Miranda to scrub in with her on a pediatric case, but Richard lures her back to general surgery with his newest acquisition: A high-tech robotic operating system. She absolutely loves it and eagerly jumps at the chance to do a second surgery with the hospital's new toy. Arizona vows to fight the Chief for Miranda's time.

Alex can't believe Izzie has decided against the surgery. "It's not just your life at stake anymore," he shouts at her. "You're having the surgery!" Derek is furious with Cristina for talking Izzie out of the surgery, until Meredith tells him she's the one who talked to Izzie. Meredith tells Derek how her mother wasn't her mother anymore once she got Alzheimer's, how she lost her dignity, her memory. Derek insists it's not the same thing, and that Izzie's condition is treatable. He orders Meredith, as his resident, to go back and talk Izzie into the surgery.

Izzie is talking over her decision with the IL2 patient when the woman collapses. Surgery doesn't go well and Izzie looks on as Swender tells the woman's family that there is no hope she'll ever be off a ventilator.

Izzie pages George to ask him what to do. "You know what to do," he says. "You've already made the decision." Izzie tells Derek he can operate, but she doesn't want to end up on a ventilator. She signs a DNR but Alex wants her to tear it up. "I can't live like this," she says. "And I can't live if something goes wrong. It's not what I want." She says she "went crazy" when Denny signed his DNR but begs Alex not to do the same thing. "If it comes down to it, just let me go," she pleads.

Owen tells Cristina he's decided to go back to Iraq, and that his nightmares are the result of "unfinished business." She tells him she doesn't want him to die. He asks her, "Come with me," and they end up on his mother's doorstep.

It's a different doctor who knocks on the army recruiter's door: George, who's inspired by the soldier's passion.

The soldier talks Callie into amputating his leg but she freezes when it comes time to cut. "We're not doing harm. We're saving him," Owen tells her.

After seeing Izzie wheeled off to surgery, Meredith says to Derek, "Let's go to City Hall tomorrow. I don't want to spend another day not being married to you."

After the surgery, Izzie wakes and is told she's fine, apart from "sluggish" kidneys. She is jubilant when Derek tells her he got the whole tumor out. But then she asks again about how the surgery went. And again. "Did you screw up her brain?" demands Alex, but Derek asks him to stay calm, that this could just be a temporary post-op condition.

Since Derek and Meredith are getting married, and won't want housemates anymore, Mark asks Lexie to move in with him. When she says she wants to wait several years, at least, he takes a patient's advice and tells her that he's "moving on" and that he's going to buy a house on his own.

After the visit to his mother, Owen tells Cristina he slept without any nightmares for the first night since he's been home. "I'm getting better," he tells her, and asks her to think about taking him back.